TREATMENT OF AMYOTROPHIC-LATERAL-SCLEROSIS USING A GENE-THERAPY APPROACH

被引:23
作者
AEBISCHER, P
KATO, AC
机构
[1] UNIV GENEVA,SCH MED,CTR MED,DEPT PHARMACOL,CH-1211 GENEVA,SWITZERLAND
[2] UNIV GENEVA,SCH MED,CTR MED,DIV CLIN NEUROMUSCULAR RES,CH-1211 GENEVA,SWITZERLAND
关键词
GENE THERAPY; AMYOTROPHIC LATERAL SCLEROSIS; NEUROTROPHIC FACTORS;
D O I
10.1159/000117095
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neurotrophic factors which act on motor neurons may provide an efficient treatment for amyotrophic lateral sclerosis. In order to overcome the difficulty of administering proteins into the central nervous system, it is possible to use a gene therapy approach, i.e. the polymer encapsulation of cells which have been genetically engineered to release one of these neurotrophic factors. The polymer-encapsulated cells can be implanted subcutaneously or even intrathecally and permit continuous, slow release of proteins. There is no rejection of the cells due to their isolation by a semi-permeable membrane, no risk of tumor formation and the polymer device can be removed in the event of a problem.
引用
收藏
页码:65 / 68
页数:4
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