INFLUENCE OF DEXTRANS ON CARDIAC PRESERVATION IN AN EXTRACORPOREAL RAT-HEART MODEL

被引：1

作者：

ALBES, M ^{[1
]}

BAUMGARTEL, I ^{[1
]}

ROHDE, R ^{[1
]}

HAUSEN, B ^{[1
]}

DEMERTZIS, S ^{[1
]}

WAHLERS, T ^{[1
]}

机构：

[1] HANNOVER MED SCH,DIV THORAC & CARDIOVASC SURG,W-3000 HANNOVER,GERMANY

来源：

EUROPEAN SURGICAL RESEARCH | 1995年 / 27卷 / 06期

关键词：

CARDIAC PRESERVATION; HEART TRANSPLANTATION; DEXTRANS; MOLECULAR WEIGHT; PERMEABILITY; EXTRACORPOREAL RAT HEART MODEL;

D O I：

10.1159/000129427

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Despite advances in preservation techniques for thoracic organs, the ischemic tolerance of the donor heart is still limited. Recently, a beneficial effect of oncotic substances such as dextran was shown in lung transplantation. Clinically, only in the University of Wisconsin (UW) solution oncotic substances for the prevention of cellular edema are used. Since little is known about the perspective value of dextrans in cardiac preservation, we investigated dextrans with different molecular weights added to the St. Thomas Hospital solution in an experimental working rat heart Langendorff model for functional and histological aspects. By comparison of various dextrans with molecular weights of 40,000, 70,000 and 160,000 daltons, best results were achieved by the addition of 5% dextran with the highest molecular weight.

引用

页码：406 / 410

页数：5

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