EFFECTS OF TRANSDERMAN NICOTINE ON MOOD AND SLEEP IN NONSMOKING MAJOR DEPRESSED-PATIENTS

被引：96

作者：

SALINPASCUAL, RJ

DELAFUENTE, JR

GALICIAPOLO, L

DRUCKERCOLIN, R

机构：

[1] NATL AUTONOMOUS UNIV MEXICO,FAC MED,DEPT FISIOL,MEXICO CITY 04510,DF,MEXICO

[2] NATL AUTONOMOUS UNIV MEXICO,FAC MED,DEPT PSICOL MED PSIQUIATRIA & SALUD MENT,MEXICO CITY 04510,DF,MEXICO

[3] NATL AUTONOMOUS UNIV MEXICO,FAC MED,INST FISIOL CELULAR,DEPT NEUROCIENCIAS,MEXICO CITY 04510,DF,MEXICO

[4] HOSP PSIQUIATRICO FRAY BERNARDINO ALVAREZ,MEXICO CITY,DF,MEXICO

来源：

PSYCHOPHARMACOLOGY | 1995年 / 121卷 / 04期

关键词：

NICOTINE; MAJOR DEPRESSION; REM SLEEP; CHOLINERGIC SYSTEM;

D O I：

10.1007/BF02246496

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of nicotine as an indirect cholinergic agent in sleep has been studied in normal subjects. There are no studies of its effects on sleep in depressed patients. Nicotine transdermal patches (17.5 mg), were studied in eight depressed patients (DSM-III-R) and eight normal volunteers. Subjects wore placebo and nicotine patches for 24 h. Depressed patients showed inreased REM sleep without changes in other sleep variables. They also showed a short term improvement of mood. Normal volunteers had sleep fragmentation, and reduction of REM sleep time. No major side effects were reported in either group.

引用

页码：476 / 479

页数：4

共 18 条

[1] EFFECTS OF NICOTINE ADMINISTRATION AND ITS WITHDRAWAL ON PLASMA-CORTICOSTERONE AND BRAIN 5-HYDROXYINDOLES [J].