PRENATAL AMPHETAMINE EXPOSURE - OVULATION, SEXUAL-BEHAVIOR AND HYPOTHALAMIC MONOAMINE CONTENT IN RATS

被引：29

作者：

RAMIREZ, OA

CARRER, HF

NASELLO, AG

机构：

[1] Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000 Córdoba

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 11卷 / 06期

关键词：

Behavioral teratogenesis; Brain monoamine metabolism; Prenatal amphetamine; Sexual behavior;

D O I：

10.1016/0091-3057(79)90250-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Previous observations have pointed out that amphetamine treatment during pregnancy produces behavioral and neurochemical changes in the male offspring. The present study was undertaken in order to determine whether those findings could be extended to sexual behavior, reproductive function and hypothalamic monoamine metabolism in female rats. It was found that offspring of amphetamine treated rats have greater sensitivity to estrogen and estrogen-progesterone for the induction of sexual receptivity. 5-HT content in medial hypothalamus of estrogen-progesterone treated rats was decreased with respect to controls. On the other hand the content of 5-HIAA was not different; noradrenaline levels in hypothalamus were also normal. Sex cycle duration and ovulatory phenomena were not affected. © 1979.

引用

页码：605 / 609

页数：5

共 20 条

[1]

ABOULENEIN HY, 1971, AM J PHARM, V143, P161

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