IMMUNOLOGICAL EFFECT OF CO-TRIMOXAZOLE ON PLATELETS

被引：28

作者：

CLAAS, FHJ ^{[1
]}

VANDERMEER, JWM ^{[1
]}

LANGERAK, J ^{[1
]}

机构：

[1] STATE UNIV LEIDEN,MED CTR,DEPT INFECT DIS,LEIDEN,NETHERLANDS

来源：

BRITISH MEDICAL JOURNAL | 1979年 / 2卷 / 6195期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1136/bmj.2.6195.898

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diminished survival of transfused platelets occurred in two patients given co-trimoxazole, and a third patient taking this drug developed thrombocytopenia. By means of an indirect immunofluorescence assay antibodies against donor platelets coated with co-trimoxazole were found in the sera in all cases. These antibodies were directed against the trimethoprim component of co-trimoxazole and not against sulphamethoxazole. Co-trimoxazole is a potent antimicrobial agent and is advocated for treatment and prophylaxis in leukaemia. Hence its adverse effect on platelets is of great importance. © 1979, British Medical Journal Publishing Group. All rights reserved.

引用

页码：898 / 899

页数：2

共 15 条

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