THE ALPHA-1-AGONIST PHENYLEPHRINE INHIBITS VOLTAGE-GATED CA-2+-CHANNELS IN VASCULAR SMOOTH-MUSCLE CELLS OF RABBIT EAR ARTERY

被引：29

作者：

DECLERCK, I ^{[1
]}

HIMPENS, B ^{[1
]}

DROOGMANS, G ^{[1
]}

CASTEELS, R ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,FYSIOL LAB,CAMPUS GASTHUISBERG,B-3000 LOUVAIN,BELGIUM

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1990年 / 417卷 / 01期

关键词：

Ca[!sup]2+[!/sup]-channels; cytosolic Ca[!sup]2+[!/sup; phenylephrine; vascular smooth muscle;

D O I：

10.1007/BF00370780

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The effects of the α1-agonist phenylephrine on the voltage-gated Ca2+-entry in vascular smooth muscle cells has been studied by measuring the agonist-induced changes of [Ca2+]i in K+-depolarized tissues. These changes have been estimated from the changes in fluorescence of the Ca2+-indicator fura-2, or have been assessed from the changes in 86Rb-efflux rate through Ca2+-activated K+-channels. Phenylephrine increases the force development in K+-depolarized tissues, but reduces [Ca2+]i and inhibits the 86Rb-efflux rate. However, in the presence of the Ca2+-entry blocker verapamil, phenylephrine increases both force development and [Ca2+]i. It is concluded that phenylephrine inhibits voltage-gated Ca2+-channels, and also induces an influx of calcium by activating a verapamil-insensitive pathway. © 1990 Springer-Verlag.

引用

页码：117 / 119

页数：3

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