FAMILIAL TRANSMISSION OF A TRANSLOCATION Y-14

被引：10

作者：

BUYS, CHCM

ANDERS, GJPA

BORKENTYPMA, JMM

BLENKERSPLATTER, JAM

VANDERHOEKVANDERVEEN, AY

机构：

[1] Department of Human Genetics, State University of Groningen, Groningen

来源：

HUMAN GENETICS | 1979年 / 53卷 / 01期

关键词：

D O I：

10.1007/BF00289465

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A translocation of heterochromatic material, brightly fluorescent after actinomycin D-DAPI staining, to the short arm of chromosome 14 was prenatally detected during cytogenetic examination of cells obtained by amniocentesis on the indication of advanced maternal age. Besides this abnormal chromosome, 43 autosomes and two X chromosomes were present. Silver staining made clear that an active nucleolus-organizing region was included in the translocation product. Both the intense fluorescence and the size of the translocated extra heterochromatic block were indicative of a Yq origin. Upon cytogenetic investigation of the parents, the mother appeared to carry the same t(Y;14) chromosome. Therefore, we expected a normal girl to be born. This was confirmed after birth. © 1979 Springer-Verlag.

引用

页码：125 / 127

页数：3

共 13 条

[1] RAPID IDENTIFICATION OF CHROMOSOMES CARRYING SILVER-STAINED NUCLEOLUS-ORGANIZING REGIONS - APPLICATION TO A CASE OF 21-21 ROBERTSONIAN TRANSLOCATION [J].