INDUCTION OF ANTIPHOSPHOLIPID AUTOANTIBODIES BY IMMUNIZATION WITH BETA-2 GLYCOPROTEIN-I (APOLIPOPROTEIN-H)

被引：184

作者：

GHARAVI, AE

SAMMARITANO, LR

WEN, JY

ELKON, KB

机构：

[1] Hospital for Special Surgery, Cornell University Medical Center, New York, NY 10021

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1992年 / 90卷 / 03期

关键词：

SYSTEMIC LUPUS ERYTHEMATOSUS; ANTIPHOSPHOSPHOLIPID SYNDROME; AUTOANTIBODIES; ANTICARDIOLIPIN COFACTOR; APO-H;

D O I：

10.1172/JCI115927

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A subset of patients with systemic lupus erythematosus has autoantibodies to acidic phospholipids. Since lipids are poor immunogens, the mechanism responsible for the induction of these antibodies is unclear. Immunization of a normal rabbit and normal mice with purified human-beta-2-glycoprotein I (apolipoprotein H) resulted in the production of high levels of two non-cross-reactive antibody populations, anti-apolipoprotein H, and antiphospholipid. The antiphospholipid antibodies had binding specificities indistinguishable from autoantibodies obtained from human and murine lupus. These findings suggest a novel mechanism for the induction of antiphospholipid autoantibodies.

引用

页码：1105 / 1109

页数：5

共 45 条

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[2]

ALLISON AC, 1971, LANCET, V2, P135

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