AGE-RELATED EFFECTS OF ISCHEMIA, LIDOCAINE AND VERAPAMIL ON OVERDRIVE-INDUCED SUPPRESSION OF VENTRICULAR PACEMAKERS IN ISOLATED RAT-HEART

被引：1

作者：

ABETE, P

FERRARA, N

LEOSCO, D

CACCESE, P

LANDINO, P

SEDERINO, S

BALBI, R

RENGO, F

机构：

[1] Istituto di Medicina Interna, Cardiologia e Chirurgia Cardiovascolare, II Facoltà di Medicina e Chirurgia, Università di Napoli, Napoli, 80131, Via S. Pansini

[2] IRCCS Medical Center, Campoli, Benevento

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 1992年 / 4卷 / 02期

关键词：

AGING; ISCHEMIA; LIDOCAINE; VENTRICULAR AUTOMATICITY; VERAPAMIL;

D O I：

10.1007/BF03324085

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The effect of age on ventricular automaticity in the isolated perfused rat heart was determined under different conditions. When the ventricle is electrically stimulated at a faster rate, drive cessation is followed by a temporary suppression of ventricular automaticity (overdrive suppression). The effects of ischemia, lidocaine and verapamil on overdrive suppression were studied in isolated perfused adult and senescent rat hearts with complete atrio-ventricular block, by monitoring ventricular escape rate and escape rhythm recovery time after 1 minute of overdrive at a constant multiple (x3) of the spontaneous rate. The results demonstrated that: 1) lidocaine decreases ventricular automaticity especially in senescent hearts; 2) verapamil does not modify ventricular automaticity in basal conditions in either adult or senescent hearts; 3) myocardial ischemia causes a reduction in ventricular automaticity and more markedly in senescent hearts; and 4) lidocaine exaggerates the effect of ischemia, while verapamil seems to antagonize its depressant effect more in adult than in senescent hearts.

引用

页码：157 / 164

页数：8

共 26 条

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