ASSIGNMENT OF G-PROTEIN SUBTYPES TO SPECIFIC RECEPTORS INDUCING INHIBITION OF CALCIUM CURRENTS

被引：560

作者：

KLEUSS, C ^{[1
]}

HESCHELER, J ^{[1
]}

EWEL, C ^{[1
]}

ROSENTHAL, W ^{[1
]}

SCHULTZ, G ^{[1
]}

WITTIG, B ^{[1
]}

机构：

[1] FREE UNIV BERLIN, INST PHARMAKOL, W-1000 BERLIN 33, GERMANY

来源：

NATURE | 1991年 / 353卷 / 6339期

关键词：

D O I：

10.1038/353043a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The inhibition of voltage-dependent Ca2+ channels in secretory cells by plasma membrane receptors is mediated by pertussis toxin-sensitive G proteins. Multiple forms of G proteins have been described, differing principally in their alpha-subunits, but it has not been possible to establish which G-protein subtype mediates inhibition by a specific receptor. By intranuclear injection of antisense oligonucleotides into rat pituitary GH3 cells, the essential role of the G(o)-type G proteins in Ca2+-channel inhibition is established: the subtypes G(o1) and G(o2) mediate inhibition through the muscarinic and somatostatin receptors, respectively.

引用

页码：43 / 48

页数：6

共 47 条

[1] GO, A GTP-BINDING PROTEIN - IMMUNOCHEMICAL AND IMMUNOHISTOCHEMICAL LOCALIZATION IN THE RAT [J].

ASANO, T ;

SEMBA, R ;

KAMIYA, N ;

OGASAWARA, N ;

KATO, K .

JOURNAL OF NEUROCHEMISTRY, 1988, 50 (04) :1164-1169

[2]

BERTRAND P, 1990, J BIOL CHEM, V265, P18576

[3] RECEPTOR-EFFECTOR COUPLING BY G-PROTEINS [J].

BIRNBAUMER, L ;

ABRAMOWITZ, J ;

BROWN, AM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1031 (02) :163-224

[4]

BIRNBAUMER LA, 1990, REV PHARM TOX, V30, P675

[5] COMPARATIVE INHIBITION OF RABBIT GLOBIN MESSENGER-RNA TRANSLATION BY MODIFIED ANTISENSE OLIGODEOXYNUCLEOTIDES [J].

CAZENAVE, C ;

STEIN, CA ;

LOREAU, N ;

THUONG, NT ;

NECKERS, LM ;

SUBASINGHE, C ;

HELENE, C ;

COHEN, JS ;

TOULME, JJ .

NUCLEIC ACIDS RESEARCH, 1989, 17 (11) :4255-4273

[6] THE TIPS LECTURE - THE NICOTINIC ACETYLCHOLINE-RECEPTOR - AN ALLOSTERIC PROTEIN PROTOTYPE OF LIGAND-GATED ION CHANNELS [J].

CHANGEUX, JP .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (12) :485-492

[7] SELECTIVE DEFICIENCY OF GUANINE NUCLEOTIDE-BINDING PROTEIN G0 IN 2 DOPAMINE-RESISTANT PITUITARY-TUMORS [J].

COLLU, R ;

BOUVIER, C ;

LAGACE, G ;

UNSON, CG ;

MILLIGAN, G ;

GOLDSMITH, P ;

SPIEGEL, AM .

ENDOCRINOLOGY, 1988, 122 (03) :1176-1178

[8]

CORNISHBOWDEN A, 1985, EUR J BIOCHEM, V150, P1

[9] THE FATE OF OOCYTE NUCLEAR PROTEINS DURING EARLY DEVELOPMENT OF XENOPUS-LAEVIS [J].

DREYER, C ;

SCHOLZ, E ;

HAUSEN, P .

WILHELM ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY, 1982, 191 (04) :228-233

[10] GUANINE NUCLEOTIDE-BINDING PROTEIN GO-INDUCED COUPLING OF NEUROPEPTIDE Y-RECEPTORS TO CA-2+ CHANNELS IN SENSORY NEURONS [J].

EWALD, DA ;

STERNWEIS, PC ;

MILLER, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (10) :3633-3637

← 1 2 3 4 5 →