STEREOSPECIFIC ANTAGONISM BY (+)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE (MCPG) OF (1S,3R)-ACPD-INDUCED EFFECTS IN NEONATAL RAT MOTONEURONS AND RAT THALAMIC NEURONS

被引：95

作者：

JANE, DE ^{[1
]}

JONES, PLS ^{[1
]}

POOK, PCK ^{[1
]}

SALT, TE ^{[1
]}

SUNTER, DC ^{[1
]}

WATKINS, JC ^{[1
]}

机构：

[1] INST OPHTHALMOL,DEPT VISUAL SCI,LONDON EC1V 9EL,ENGLAND

来源：

NEUROPHARMACOLOGY | 1993年 / 32卷 / 07期

关键词：

STEREOSPECIFICITY; METABOTROPIC GLUTAMATE RECEPTORS; THALAMUS; SPINAL CORD; MCPG;

D O I：

10.1016/0028-3908(93)90088-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The (+)-enantiomer of alpha-methyl-4-carboxyphenylglycine (MCPG) stereoslectively antagonized the depolarization of neonatal rat motoneurones and the excitation of rat thalamic neurons induced by the specific metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD). (+)-MCPG preferentially reduced (1S,3R)-ACPD-induced responses relative to responses induced by (S)-alpha-amino-3-hydorxy-5-methylisoxazole-4-propionic acid (AMPA) and N-methyl-D-aspartate (NMDA).

引用

页码：725 / 727

页数：3

共 9 条

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