A USEFUL APPLICATION OF BENZYL TRICHLOROACETIMIDATE FOR THE BENZYLATION OF ALCOHOLS

被引：71

作者：

ECKENBERG, P ^{[1
]}

GROTH, U ^{[1
]}

HUHN, T ^{[1
]}

RICHTER, N ^{[1
]}

SCHMECK, C ^{[1
]}

机构：

[1] UNIV GOTTINGEN,INST ORGAN CHEM,TAMMANNSTR 2,W-3400 GOTTINGEN,GERMANY

来源：

TETRAHEDRON | 1993年 / 49卷 / 08期

关键词：

D O I：

10.1016/S0040-4020(01)80349-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Primary, secondary and tertiary alcohols, which are sensitive under basic or acidic reaction conditions, can be O-benzylated under mild acidic reaction conditions using benzyl 2,2,2-trichloroacetimidate as the benzylation agent. Chiral substrates, which have a tendency towards racemization under basic reaction conditions, can be benzylated without any loss of chirality.

引用

页码：1619 / 1624

页数：6

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