LINKAGE STUDIES OF PSYCHIATRIC-DISORDERS

被引：25

作者：

RISCH, N

MERIKANGAS, KR

机构：

[1] YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH,NEW HAVEN,CT 06510

[2] YALE UNIV,SCH MED,DEPT GENET,NEW HAVEN,CT 06510

[3] YALE UNIV,SCH MED,DEPT PSYCHIAT,NEW HAVEN,CT 06510

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 1993年 / 243卷 / 3-4期

关键词：

GENETICS; LINKAGE; PSYCHIATRIC DISORDERS; GENETIC EPIDEMIOLOGY;

D O I：

10.1007/BF02190720

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Linkage analysis has been successful in identifying the genetic basis of numerous Mendelian diseases. These successes were due in part to the rapid developments in molecular biology, which have yielded a plethora of informative genetic markers. Although there is strong evidence that the manifestation of schizophrenia and bipolar affective disorders is controlled by genes, no evidence for linkage has been established. For psychiatric disorders, the most important limiting factor is likely to be the lack of single loci with very large effects that occur with any relevant frequency. The difficulties of linkage studies in psychiatric disorders are discussed with reference to non-psychiatric genetic diseases for which linkage to genetic markers has been successful. Recommendations for collecting information to clarify the patterns of transmission of the psychiatric disorders are described.

引用

页码：143 / 149

页数：7

共 31 条

[1] LINKAGE ANALYSIS BETWEEN THE MAJOR HISTOCOMPATIBILITY SYSTEM AND INSULIN-DEPENDENT DIABETES IN FAMILIES WITH PATIENTS IN 2 CONSECUTIVE GENERATIONS [J].