REARRANGEMENT AND EXPRESSION OF MDM(2) ONCOGENE IN CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：13

作者：

HUANG, YQ

RAPHAEL, B

BUCHBINDER, A

LI, JJ

ZHANG, WG

FRIEDMANKIEN, AE

机构：

[1] NYU,MED CTR,DEPT MICROBIOL,NEW YORK,NY 10016

[2] NYU,MED CTR,DEPT DERMATOL,NEW YORK,NY 10016

[3] NYU,MED CTR,DEPT MED,NEW YORK,NY 10016

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1994年 / 47卷 / 02期

关键词：

MDM(2) GENE REARRANGEMENT; CLL; TRISOMY; 12;

D O I：

10.1002/ajh.2830470215

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since trisomy 12 is the most common chromosome abnormality found in CLL and MDM(2) has been mapped to this chromosome, we examined the possible association of MDM, in the pathogenesis of CLL. A rearrangement of the MDM(2) gene was observed in 4 of 11 peripheral blood mononuclear cells (PBMC) from patients with CLL by Southern blot hybridization. Expression of MDM(2) was detected in all of the CLL samples examined by Northern blot. However, neither gross amplification nor overexpression of the MDM(2) gene was found in CLL. The data suggest that MDM(2) may play a role in the pathogenesis of CLL and may help to explain how abnormalities of chromosome 12 are related to CLL. (C) 1994 Wiley-Liss, Inc.

引用

页码：139 / 141

页数：3

共 11 条

[1]

BUESORAMOS CE, 1993, BLOOD, V82, P2617

[2] THE MDM-2 ONCOGENE CAN OVERCOME WILD-TYPE P53 SUPPRESSION OF TRANSFORMED-CELL GROWTH [J].