ACETYLCHOLINE RELEASE FROM MOTOR-NERVE ENDINGS IN RATS TREATED WITH NEOSTIGMINE

被引：49

作者：

ROBERTS, DV

THESLEFF, S

机构：

[1] Department of Pharmacology, University of Lund

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1969年 / 6卷 / 03期

关键词：

Acetylcholine release; Myasthenia gravis; Neostigmine; Neuromuscular transmission; Quantum content;

D O I：

10.1016/0014-2999(69)90186-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rats injected subcutaneously with 100 μg neostigmine twice daily for 5-7 days were less active and appeared to have muscular weakness. The mean endplate potential quantum content of treated rats was lower than normal, as was the number of quanta readily available for release. It was concluded that treated rats released less acetylcholine per nerve impulse than did normal rats. The findings are discussed in relation to the treatment of myasthenia gravis. © 1969.

引用

页码：281 / &

共 6 条

[1] A QUANTITATIVE STUDY OF END-PLATE POTENTIALS IN ISOLATED HUMAN MUSCLE [J].