IDIOPATHIC NEUTROPENIA WITH NORMO-CELLULAR BONE-MARROW - IMMUNE-COMPLEX DISEASE

被引：30

作者：

CALIGARISCAPPIO, F

CAMUSSI, G

GAVOSTO, F

机构：

[1] UNIV TURIN, CATTEDRA PATOL SPECIALE MEDICA 1, IST MED INTERNA, I-10126 TURIN, ITALY

[2] UNIV TURIN, CATTEDRA NEFROL MED, I-10126 TURIN, ITALY

[3] OSPED MAGGIORE S GIOVANNI BATTISTA & TORINO, TORINO, ITALY

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1979年 / 43卷 / 04期

关键词：

D O I：

10.1111/j.1365-2141.1979.tb03792.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The presence of circulating immune-complexes (IC) and their in vivo interaction with polymorphonuclear neutrophils (PMN) were detected in 2 cases of idiopathic neutropenia with normocellular bone marrow. Injection of patients'' sera into New Zealand White rabbits caused a striking neutropenia due to sequestration of PMN in the vascular bed of kidneys and lungs. The kinetics of PMN disappearance from peripheral blood and the pattern of sequestration overlapped that induced by injection of pre-formed soluble IC. Treatment with plasmapheresis caused an early and lasting increase of PMN; rabbit PMN were almost unaffected by injection of patient serum after plasmapheresis. These data are consistent with the possibility that idiopathic neutropenia with normocellular bone marrow may be caused by persistent in vivo interaction between IC and circulating PMN.

引用

页码：595 / 605

页数：11

共 17 条

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