PARTITION-COEFFICIENTS OF QUINONES AND HYDROQUINONES AND THEIR RELATION TO BIOCHEMICAL REACTIVITY

被引：72

作者：

RICH, PR

HARPER, R

机构：

[1] Glynn Research Institute, Bodmin

来源：

FEBS LETTERS | 1990年 / 269卷 / 01期

关键词：

Hydroquinone; Partition coefficient; Plastoquinone; Quantitative structure-activity relationship; Quinol; Quinone; Quinone analogue; Steric specificity; Ubiquinone;

D O I：

10.1016/0014-5793(90)81139-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some major effects of ring substituents on the partition coefficients of quinone headgroups are described. Attention is drawn to the large differences in partition coefficients in cyclohexane/water of the two major freely diffusing redox forms, the quinone, Q, and the hydroquinone, QH2. Methoxy substituents cause a marked increase of the cyclohexane/water partition coefficient of the hydroquinone, but this effect is absent in the quinone and is also not seen in measurements in octanol/water. The relation between partition coefficients and biochemical specificity of quinone binding sites is explored. © 1990.

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页码：139 / 144

页数：6

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