DIVERGENT CHANGES OF CHROMOGRANIN-A SECRETOGRANIN-II LEVELS IN DIFFERENTIATING HUMAN NEUROBLASTOMA-CELLS

被引：60

作者：

WEILER, R

MEYERSON, G

FISCHERCOLBRIE, R

LASLOP, A

PAHLMAN, S

FLOOR, E

WINKLER, H

机构：

[1] UNIV INNSBRUCK, DEPT PHARMACOL, PETER MAYR STR 1A, A-6020 INNSBRUCK, AUSTRIA

[2] UNIV UPPSALA, DEPT PATHOL, S-75105 UPPSALA, SWEDEN

[3] UNIV WISCONSIN, DEPT ANAT, MADISON, WI 53706 USA

来源：

FEBS LETTERS | 1990年 / 265卷 / 1-2期

关键词：

Chromogranin A; Neuroblastoma; Secretogranin II; SV2; Synaptin/synaptophysin;

D O I：

10.1016/0014-5793(90)80875-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human neuroblastoma cells were cultured either in the absence or presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) known to induce neuronal differentiation. This treatment led to a marked increase in the concentration of secretogranin II but to a decrease of chromogranin A. Analogous changes were observed for the respective mRNAs. Thus during differentiation of these cells the biosynthesis of two vesicle constituents of large dense core vesicles is differentially regulated as determined both at the mRNA and the protein level. Levels of both synaptin/synaptophysin and SV2 were also elevated but to a smaller degree than that of secretogranin II. © 1990.

引用

页码：27 / 29

页数：3

共 32 条

[1] MUSCARINIC RECEPTORS IN HUMAN SH-SY5Y NEUROBLASTOMA CELL-LINE - REGULATION BY PHORBOL ESTER AND RETINOIC ACID-INDUCED DIFFERENTIATION [J].