ABNORMALITIES OF CENTRAL MOTOR CONDUCTION IN PARKINSONS-DISEASE

被引：38

作者：

KANDLER, RH ^{[1
]}

JARRATT, JA ^{[1
]}

SAGAR, HJ ^{[1
]}

GUMPERT, EJW ^{[1
]}

VENABLES, GS ^{[1
]}

DAVIESJONES, GAB ^{[1
]}

JORDAN, N ^{[1
]}

机构：

[1] ROYAL HALLAMSHIRE HOSP,DEPT NEUROL,SHEFFIELD S10 2JF,S YORKSHIRE,ENGLAND

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1990年 / 100卷 / 1-2期

关键词：

MAGNETIC STIMULATION; CENTRAL MOTOR CONDUCTION; PARKINSONS DISEASE;

D O I：

10.1016/0022-510X(90)90018-I

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The new technique of magnetic stimulation was used to measure amplitude of the motor evoked potential (MEP) recorded from abductor digiti minimi whilst stimulating at the head, and motor conduction time (MCT) between head and neck. Bilateral studies were made in 12 normal subjects and 56 patients with Parkinson's disease. The amplitudes of the MEPs were significantly larger (P < 0.05) in the patients (mean 1.6 mV, SD 1.4) compared with the normal subjects (mean 0.9 mV, Se 0.6). MCTs were significantly shorter (P < 0.001) in patients (mean 8.1 ms, SD 1.3) compared with the normal subjects (mean 9.4 ms, SD 1.2). Although the pathophysiological basis of these changes has not been determined, they provide objective measurements which may be clinically valuable in monitoring therapy.

引用

页码：94 / 97

页数：4

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