PARADOXICAL EFFECTS OF MATERNAL STRESS ON FETAL STEROIDS AND POSTNATAL REPRODUCTIVE TRAITS IN FEMALE MICE FROM DIFFERENT INTRAUTERINE POSITIONS

被引:121
作者
VOMSAAL, FS
QUADAGNO, DM
EVEN, MD
KEISLER, LW
KEISLER, DH
KHAN, S
机构
[1] UNIV MISSOURI, DALTON RES CTR, COLUMBIA, MO 65211 USA
[2] UNIV MISSOURI, DEPT ANIM SCI, COLUMBIA, MO 65211 USA
[3] FLORIDA STATE UNIV, DEPT BIOL SCI, TALLAHASSEE, FL 32306 USA
关键词
D O I
10.1095/biolreprod43.5.751
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We examined effects of maternal stress on prenatal serum concentrations of testosterone and estradiol and on postnatal reproductive traits in female mice from different intrauterine positions. On Day 18 of fetal life, control females positioned in utero between two male fetuses (2M females) had higher concentrations of testosterone and lower concentrations of estradiol in serum than control female fetuses located between two females (0M females). Control females positioned between a male and a female fetus (1M females) had intermediate levels of both hormones. Prior intrauterine position in control females accounted for differences in genital morphology (length of the anogenital separation) at birth and length of estrous cycles during adulthood. Maternal stress eliminated these postnatal differences due to prior intrauterine position: all 0M, 1M, and 2M female offspring of stressed mothers exhibited postnatal traits that were indistinguishable from those of control 2M females. Maternal stress resulted in an increase of over 1 ng/ml in serum testosterone in all female fetuses; the magnitude of the increase was similar for 0M, 1M, and 2M females. There was no effect of maternal stress on serum concentrations of estradiol in 0M and 2M female fetuses. Maternal stress resulted in a dramatic change in the postnatal traits of 0M females, whereas 2M females showed no change. Since the effect of maternal stress on sex steroids was similar among fetuses from different intrauterine positions but postnatal response to maternal stress varied by intrauterine position, other components of the endocrine system may mediate effects of maternal stress on these postnatal characteristics.
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页码:751 / 761
页数:11
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