N-ACYL 3-ALKYLIDENYL-AZETIDIN-2-ONES AND 3-ALKYL AZETIDIN-2-ONES - A NEW CLASS OF MONOCYCLIC BETA-LACTAM ANTIBACTERIAL AGENTS .1. STRUCTURE-ACTIVITY-RELATIONSHIPS OF 3-ISOPROPYLIDENE AND 3-ISOPROPYL ANALOGS

被引：10

作者：

BRICKNER, SJ

GAIKEMA, JJ

ZURENKO, GE

GREENFIELD, LJ

MANNINEN, PR

ULANOWICZ, DA

机构：

[1] Upjohn Laboratories, The Upjohn Company, Kalamazoo

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 02期

关键词：

D O I：

10.7164/antibiotics.45.213

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The synthesis and antibacterial activity of a series of N-acyl 3-isopropylidenyl- and 3-isopropyl 2-azetidinones having potent in vitro antibacterial activity, particularly against anaerobic organisms, is described. A distinguishing structural feature of these compounds is the lack of any ionizable moiety appendant to the lactam nitrogen.

引用

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页码：213 / 226

页数：14

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