ROLE OF ENDOGENOUS ENDOTHELIN IN THE DEVELOPMENT OF HYPERTENSION IN RATS

被引：14

作者：

TAKAGI, Y

FUKASE, M

TAKATA, S

KAWAKAMI, M

MASUI, M

UEDA, M

FUJITA, T

机构：

[1] Third Division, Department of Medicine, Kobe University School of Medicine, Osaka

[2] Kobe and Shionogi Research Laboratories, Shionogi Co Ltd, Osaka

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 04期

关键词：

ENDOTHELIN; ESSENTIAL HYPERTENSION; SPONTANEOUSLY HYPERTENSIVE RATS (SHR); STROKE PRONE SHR (SHR-SP);

D O I：

10.1093/ajh/4.4.389

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

To further elucidate the pathophysiologic role of endogenous endothelin (ET), we have studied the chronic effect of anti-ET gamma-globulin on the development of hypertension in spontaneously hypertensive rats (SHR) and stroke prone SHR (SHR-SP) for three weeks. In neither SHR nor SHR-SP did repetitive bolus injection of anti-ET gamma-globulin suppress the rise in blood pressure. The present data suggest that endogenous ET is not likely to play a key role in the development of hypertension, although ET may induce a local vasoconstriction at the injured vascular wall.

引用

页码：389 / 391

页数：3

共 11 条

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