CFTR, A CHANNEL WITH THE STRUCTURE OF A TRANSPORTER

被引：37

作者：

RIORDAN, JR

CHANG, XB

机构：

[1] UNIV TORONTO,DEPT BIOCHEM,TORONTO M5S 1A1,ONTARIO,CANADA

[2] UNIV TORONTO,DEPT CLIN BIOCHEM,TORONTO M5S 1A1,ONTARIO,CANADA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1101卷 / 02期

关键词：

CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MEMBRANE TRANSPORT;

D O I：

10.1016/0005-2728(92)90230-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to a superfamily of active transport molecules. However, when expressed in a wide variety of heterologous cell systems and when purified to homogeneity and reconstituted in planar lipid bilayers, it exhibits low conductance chloride channel activity. We postulate that the active transport capability of the molecule has been adapted to provide very stringent metabolic control of this channel which is responsible for chloride secretion and hydration of wet epithelial surfaces.

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页码：221 / 222

页数：2

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