HORMONES IN SELF-TOLERANCE AND AUTOIMMUNITY - A ROLE IN THE PATHOGENESIS OF RHEUMATOID-ARTHRITIS

被引：24

作者：

BERCZI, I

BARAGAR, FD

CHALMERS, IM

KEYSTONE, EC

NAGY, E

WARRINGTON, RJ

机构：

[1] Department of Immunology, University of Manitoba, Winnipeg, MB

[2] Rheumatic Disease Unit, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba

[3] Rheumatic Disease Unit, Wellesley Hospital, University of Toronto, Toronto, ON

来源：

AUTOIMMUNITY | 1993年 / 16卷 / 01期

基金：

英国医学研究理事会;

关键词：

HORMONES; SELF TOLERANCE; IMMUNOREGULATION; THYMUS; AUTOIMMUNITY; RHEUMATOID ARTHRITIS;

D O I：

10.3109/08916939309010647

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies indicate that pituitary hormones play an important role in immunoregulation. The evidence that endocrine abnormalities are associated with, and may contribute to the development of autoimmune disease is reviewed and discussed. Patients suffering from rheumatoid arthritis show a number of endocrine abnormalities that indicate altered pituitary function. The decreased bioactivity of prolactin and possible inadequate glucocorticoid response to inflammation found in patients may have an etiological role in rheumatoid arthritis. The further clarification of the possible role of endocrine factors in the etiology of autoimmune disease is needed urgently.

引用

页码：45 / 56

页数：12

共 141 条

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