B-CELL ANTIGEN RECEPTORS

被引：44

作者：

RETH, M

机构：

[1] Max-Planck Institut für Immunbiologie, D-7100 Freiburg

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 01期

关键词：

D O I：

10.1016/0952-7915(94)90026-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen receptor is functionally divided into the ligand-binding immunoglobulin (Ig) molecule and the signal-transducing Ig-alpha/Ig-beta heterodimer. This knowledge has been exploited to design variant antigen receptors which combine both functions in a single molecule.

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页码：3 / 8

页数：6

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