A NEW PUTATIVE 5-HT1A RECEPTOR ANTAGONIST OF THE 1-ARYLPIPERAZINE CLASS OF LIGANDS

被引：23

作者：

CHOJNACKAWOJCIK, E

KLODZINSKA, A

DRABCZYNSKA, A

PAWLOWSKI, M

CHARAKCHIEVAMINOL, S

CHLON, G

GORCZYCA, M

机构：

[1] JAGIELLONIAN UNIV,COLLEGIUM MEDICUM,DEPT CHEM TECHNOL DRUGS,PL-30688 KRAKOW,POLAND

[2] JAGIELLONIAN UNIV,COLLEGIUM MEDICUM,DEPT PHARMACEUT CHEM,PL-30688 KRAKOW,POLAND

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 30卷 / 7-8期

关键词：

1-ARYLPIPERAZINE; 5-HT1A-ANTAGONIST; 5-HT1A-PARTIAL AGONIST;

D O I：

10.1016/0223-5234(96)88273-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

5-HT1A and 5-HT2A receptor affinities of several omega-alkyl-1-arylpiperazines containing a terminal pyrimidopurine or 1,3-diazepinopurine ring system are reported. Several behavioral models demonstrated that 1,3-dimethyl-9-[3-(4-phenyl-1-piperazinyl)propyl]-2,4,8-trioxo-1,3,9-trihydropyrimidino[2,1-f]purine 8 and its analogs 5 and 6 may be classified as 5-HT1A postsynaptic antagonists, whereas 7, 9 and 10 are partial agonists of 5-HT1A receptors.

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收藏

页码：587 / 592

页数：6

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