EFFECTS OF MATERNAL AND SIBLING DEPRIVATION ON BASAL AND STRESS-INDUCED HYPOTHALAMIC-PITUITARY-ADRENAL COMPONENTS IN THE INFANT RAT

被引：73

作者：

AVISHAIELINER, S

YI, SJ

NEWTH, CJL

BARAM, TZ

机构：

[1] UNIV SO CALIF, CHILDRENS HOSP LOS ANGELES, DIV NEUROL, LOS ANGELES, CA 90027 USA

[2] UNIV SO CALIF, CHILDRENS HOSP LOS ANGELES, DIV CRIT CARE, LOS ANGELES, CA 90027 USA

来源：

NEUROSCIENCE LETTERS | 1995年 / 192卷 / 01期

关键词：

MATERNAL DEPRIVATION; STRESS; INFANT RAT; DEVELOPMENT; CORTICOSTERONE; CORTICOTROPIN RELEASING HORMONE; MESSENGER RNA; HYPOTHALAMIC-PITUITARY-ADRENAL;

D O I：

10.1016/0304-3940(95)11606-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Prolonged maternal deprivation during early infancy increases basal- and stress-induced corticosterone (CORT) levels, but the underlying mechanism is not clear. In general, stressors activate the hypothalamic-pituitary-adrenal (HPA) axis, with secretion and compensatory synthesis of hypothalamic corticotropin-releasing hormone (CRH). In the infant rat, we have demonstrated that maximally tolerated acute cold stress induced a robust elevation of plasma CORT throughout the first 2 postnatal weeks. However CRH messenger RNA (CRH-mRNA) abundance 4 h subsequent to cold stress was enhanced only in rats aged 9 days or older. This suggests a developmental regulation of the CRH component of the HPA-response to this stressor. The present study examined whether increased basal and cold stress-induced CORT levels after 24 h of maternal deprivation were due to enhanced CRH-mRNA abundance in the hypothalamic paraventricular nucleus (PVN). CRH-mRNA abundance, and basal- and cold-induced plasma CORT levels were measured in maternally deprived 6 and 9-day-old pups compared to non-deprived controls. Maternal deprivation increased basal and cold-induced CORT levels on both 6 and 9-day-old rats. CRH-mRNA abundance in the PVN of deprived rats did not differ from that in non-deprived rats. Our results indicate that the enhanced basal and stress-induced plasma CORT observed after 24 h maternal deprivation is not due to increased CRH-mRNA abundance in the PVN.

引用

页码：49 / 52

页数：4

共 25 条

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