NEWER ANTIVIRAL AGENTS - COMPARATIVE ASSAYS IN VIVO AND IN VITRO

被引：5

作者：

HYNDIUK, RA

KAUFMAN, HE

ELLISON, E

CENTIFANTO, Y

机构：

[1] Department of Ophthalmology, University of Florida, Gainesville, FL

来源：

CHEMOTHERAPY | 1968年 / 13卷 / 03期

关键词：

D O I：

10.1159/000220542

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In vivo and in vitro antiviral activity of Trifluorothymidinc (FsTDR), Iododeoxyuridine (IDU), Methylaminodeoxyuridine (MADU), Cytosine Arabinoside (CA), and Phagicin were compared using the standard model of herpetic keratitis in rabbits, and an agar diffusion plaque inhibition system. All of these drugs were active in vivo. F3TDR, IDU, and CA showed good antiviral activity in vitro. MADU demonstrated cellular toxicity in vitro. Phagicin showed no in vitro activity in the agar system, but was active when methylcellulose overlay was used in another study. The solid-media system represents a satisfactory in vitro correlate for the rabbit herpetic keratitis model. © 1968 S. Karger AG, Basel.

引用

页码：139 / +

页数：1

共 19 条

[1] BURNS RP, 1963, ARCH OPHTHALMOL-CHIC, V70, P381
[2] CENTIFANTO Y, 1965, P SOC EXP BIOL MED, V120, P607, DOI 10.3181/00379727-120-30603
[3] HERRMANN EC, 1961, PROG MED VIROL, V3, P158
[4] HERRMANN EC, 1960, P SOC EXP BIOL MED, V103, P625, DOI 10.3181/00379727-103-25617
[5] HERRMANN EC, 1961, P SOC EXP BIOL MED, V107, P142, DOI 10.3181/00379727-107-26560
[6] HERRMANN EC, 1965, ANN NY ACAD SCI, V130, P69
[7] HYNDIUK RA, 1967, ARCH OPHTHALMOL-CHIC, V78, P600
[8] TREATMENT OF HERPES SIMPLEX OF CORNEA WITH IDU - DOUBLE-BLIND STUDY
JEPSON, CN
[J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 1964, 57 (02) : 213 - &
[9] OBSERVATIONS ON ANTIVIRAL SCREENING
JOHNSON, IS
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1965, 130 (A1) : 52 - +
[10] KAUFMAN H. E., 1965, PROG MED VIROL, V7, P116

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