Preparation of alkyl (R)-(-)-3-hydroxybutyrate by acidic alcoholysis of poly-(R)-(-)-3-hydroxybutyrate

被引：47

作者：

Lee, Y

Park, SH

Lim, IT

Han, KB

Lee, SY

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem Engn, Taejon 305701, South Korea

[2] Biotech Res Inst II, LG Chem, Taejon 305380, South Korea

来源：

ENZYME AND MICROBIAL TECHNOLOGY | 2000年 / 27卷 / 1-2期

关键词：

polyhydroxybutyrate; poly-(R)-(-)-(3-hydroxybutyrate); (R)-(-)-3-hydroxybutyric acid; alkyl (R)-(-)-3-hydroxybutyrate; alcoholysis;

D O I：

10.1016/S0141-0229(00)00146-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An efficient method for the preparation of optically active alkyl (R)-(-)-3-hydroxybutyrates by chemical depolymerization of biopolymer, poly-(R)-(-)-(3-hydroxybutyrate), was established. This method consists of simple recovery of poly-(R)-(-)-(3-hydroxybutyrate) from bacterial cells followed by acidic alcoholysis. When poly-(R)-(-)-(3-hydroxybutyrate) was purified by a simple digestion method that used 0.2 N sodium hydroxide, alkyl (R)-(-)-hydroxybutyrates were most efficiently produced by alcoholysis with anhydrous hydrochloric acid. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：33 / 36

页数：4

共 16 条

[1] A SYNTHETIC APPROACH TO (+)-THIENAMYCIN FROM METHYL (R)-3-HYDROXYBUTANOATE - A NEW ENTRY TO (3R,4R)-3-[(R)-1-HYDROXYETHYL]-4-ACETOXY-2-AZETIDINONE [J].