CONTINUOUS, HYPERFRACTIONATED, ACCELERATED RADIOTHERAPY (CHART) IN NON-SMALL-CELL CARCINOMA OF THE BRONCHUS

被引:84
作者
SAUNDERS, MI
DISCHE, S
机构
[1] Marie Curie Research Wing, Regional Center for Radiotherapy and Oncology, Mount Vernon Hospital, Northwood
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1990年 / 19卷 / 05期
关键词
Acceleration; Bronchial carcinoma; Hyperfractionation; Non-small cell; Radiotherapy;
D O I
10.1016/0360-3016(90)90231-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Between January 1985 and December 1988, 62 patients with locally advanced carcinoma of the bronchus were treated by radiotherapy using continuous, hyperfractionated, accelerated radiotherapy (CHART). With this regime on each of 12 consecutive days 3 fractions were given with a time interval of 6 hr between each. Initially a dose fraction of 1.4 Gy was used and a total of 50.4 Gy was achieved in 23 patients. As tolerance was good, the dose increment was raised to 1.5 Gy and the total to 54 Gy in the subsequent 39 patients. Esophagitis was the only immediate complication, and although most patients were reduced to a fluid diet for a period, recovery was complete and only one patient required endo-esophageal tube feeding for a short time. The results observed so far have been assessed against those in a previous trial of a radiosensitizer in cases similarly accepted for treatment. Complete regression, as observed radiologically, was achieved by 42%; this can be compared with 15% of the previously treated series. At 1 year the survival probability was 64% compared with a previous 44% and at 2 years 34% compared with a previous 12%. A randomized controlled clinical trial is now planned. © 1990.
引用
收藏
页码:1211 / 1215
页数:5
相关论文
共 23 条
  • [1] THE TREATMENT OF INOPERABLE LUNG-CANCER BY RADIOTHERAPY AND CHEMOTHERAPY
    BLEEHEN, NM
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1980, 6 (08): : 1007 - 1012
  • [2] Cox J D, 1988, Front Radiat Ther Oncol, V22, P121
  • [3] COX JD, 1979, CANCER, V44, P94, DOI 10.1002/1097-0142(197907)44:1<94::AID-CNCR2820440117>3.0.CO
  • [4] 2-O
  • [5] COX JD, 1986, CHEST S, V89, pS285
  • [6] DILLMAN RO, 1988, P AN M AM SOC CLIN, V7, P195
  • [7] THE RATIONALE FOR CONTINUOUS, HYPERFRACTIONATED, ACCELERATED RADIOTHERAPY (CHART)
    DISCHE, S
    SAUNDERS, MI
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1990, 19 (05): : 1317 - 1320
  • [8] EMAMI B, 1988, INT J RADIAT ONCOL, V14, P1021
  • [9] ACTUAL GROWTH-RATE AND TUMOR-CELL PROLIFERATION IN HUMAN PULMONARY NEOPLASMS
    KERR, KM
    LAMB, D
    [J]. BRITISH JOURNAL OF CANCER, 1984, 50 (03) : 343 - 349
  • [10] RADIOTHERAPY AS AN ALTERNATIVE TO SURGERY IN ELDERLY PATIENTS WITH RESECTABLE LUNG-CANCER
    NOORDIJK, EM
    CLEMENT, EV
    HERMANS, J
    WEVER, AMJ
    LEER, JWH
    [J]. RADIOTHERAPY AND ONCOLOGY, 1988, 13 (02) : 83 - 89