PREVENTION BY INTERLEUKIN-1 OF INTRACISTERNALLY INJECTED THYROTROPIN-RELEASING-HORMONE (TRH)-INDUCED GASTRIC-MUCOSAL LESIONS IN RATS

被引：11

作者：

OKUMURA, T

UEHARA, A

KITAMORI, S

OKAMURA, K

TAKASUGI, Y

NAMIKI, M

机构：

[1] Department of Internal Medicine (III), Asahikawa Medical College, Asahikawa, Hokkaido

来源：

NEUROSCIENCE LETTERS | 1991年 / 125卷 / 01期

关键词：

CENTRAL NERVOUS SYSTEM; CYTOPROTECTION; GASTRIC SECRETION; GASTRIC ULCER; INTERLEUKIN-1; THYROTROPIN-RELEASING HORMONE (TRH);

D O I：

10.1016/0304-3940(91)90123-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have recently found that interleukin-1 (IL-1) acts in the central nervous system to potently inhibit gastric acid and pepsin secretion in rats. In the present study, we examined the effects of IL-1 on the development of gastric mucosal lesions induced by intracisternal (i.c.) thyrotropin-releasing hormone (TRH), a neuropeptide known to centrally stimulate gastric secretion. Pretreatment with i.c. injected IL-1 (10 ng/rat) significantly suppressed the severity of TRH-induced gastric erosions. On the other hand, the same dose of i.c. injected IL-1 failed to exert a cytoprotective action for the gastric mucosa against orally administered absolute ethanol. These results suggest that IL-1 has an anti-ulcer effect mainly through its inhibitory action on gastric secretion.

引用

收藏

页码：31 / 33

页数：3

相关论文

共 11 条

[1] GASTRIC-EROSIONS INDUCED BY INTRACISTERNAL THYROTROPIN-RELEASING-HORMONE (TRH) IN RATS [J].

GOTO, Y ;

TACHE, Y .

PEPTIDES, 1985, 6 (01) :153-156

[2] THYROTROPIN-RELEASING-HORMONE - MEDULLARY SITE OF ACTION TO INDUCE GASTRIC-ULCERS AND STIMULATE ACID-SECRETION [J].

HERNANDEZ, DE ;

EMERICK, SG .

BRAIN RESEARCH, 1988, 459 (01) :148-152

[3] PURIFICATION AND CHARACTERIZATION OF RECOMBINANT HUMAN INTERLEUKIN-1-BETA PRODUCED IN ESCHERICHIA-COLI [J].

KIKUMOTO, Y ;

HONG, YM ;

NISHIDA, T ;

NAKAI, S ;

MASUI, Y ;

HIRAI, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 147 (01) :315-321

[4] GASTRIC-LESIONS INDUCED BY KAINIC ACID INJECTION INTO THE DORSAL MOTOR NUCLEUS OF THE VAGUS NERVE IN RATS [J].

OKUMURA, T ;

OKAMURA, K ;

KITAMORI, S ;

HARA, H ;

SHIBATA, Y ;

NAMIKI, M .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1989, 24 :15-18

[5] INHIBITION OF GASTRIC PEPSIN-SECRETION BY PERIPHERALLY OR CENTRALLY INJECTED INTERLEUKIN-1 IN RATS [J].

OKUMURA, T ;

UEHARA, A ;

OKAMURA, K ;

TAKASUGI, Y ;

NAMIKI, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 167 (03) :956-961

[6]

ROBERT A, 1979, GASTROENTEROLOGY, V77, P433

[7] THYROTROPIN-RELEASING-HORMONE - CNS ACTION TO STIMULATE GASTRIC-ACID SECRETION [J].

TACHE, Y ;

VALE, W ;

BROWN, M .

NATURE, 1980, 287 (5778) :149-151

[8] INTERLEUKIN-1 STIMULATES ACTH RELEASE BY AN INDIRECT ACTION WHICH REQUIRES ENDOGENOUS CORTICOTROPIN RELEASING-FACTOR [J].

UEHARA, A ;

GOTTSCHALL, PE ;

DAHL, RR ;

ARIMURA, A .

ENDOCRINOLOGY, 1987, 121 (04) :1580-1582

[9] INTERLEUKIN-1 - A CYTOKINE THAT HAS POTENT ANTISECRETORY AND ANTIULCER ACTIONS VIA THE CENTRAL-NERVOUS-SYSTEM [J].

UEHARA, A ;

OKUMURA, T ;

KITAMORI, S ;

TAKASUGI, Y ;

NAMIKI, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 173 (02) :585-590

[10] INTERLEUKIN-1 INHIBITS THE SECRETION OF GASTRIC-ACID IN RATS - POSSIBLE INVOLVEMENT OF PROSTAGLANDIN [J].

UEHARA, A ;

OKUMURA, T ;

SEKIYA, C ;

OKAMURA, K ;

TAKASUGI, Y ;

NAMIKI, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 162 (03) :1578-1584