SYNTHESIS OF RACEMIC CARBOACYCLONUCLEOSIDES DERIVED FROM BUTANE-1,4-DIOL AND HEXANE-1,6-DIOL

被引：14

作者：

PERBOST, M ^{[1
]}

LUCAS, M ^{[1
]}

CHAVIS, C ^{[1
]}

IMBACH, JL ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,CNRS,CHIM BIOORGAN LAB 488,CASE 008,F-34095 MONTPELLIER 5,FRANCE

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 08期

关键词：

D O I：

10.1080/07328319208021191

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of racemic diethyl succinate and dimethyl adipate substituted in their 2 and 3 position respectively by usual heterocyclic bases are described via the Michael addition of nucleobases on diethyl maleate and dimethyl (E)-3-hexene-1, 6-dioate. The Michael adducts are further reduced to afford the corresponding carboacyclonucleosides.

引用

页码：1489 / 1505

页数：17

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