BRIEF REPORT - RECURRENT ACYCLOVIR-RESISTANT GENITAL HERPES IN AN IMMUNOCOMPETENT PATIENT

被引：132

作者：

KOST, RG

HILL, EL

TIGGES, M

STRAUS, SE

机构：

[1] NIAID, CLIN INVEST LAB,MED VIROL SECT,BLDG 10, ROOM 11N228, BETHESDA, MD 20892 USA

[2] BURROUGHS WELLCOME CO, DIV VIROL, RES TRIANGLE PK, NC 27709 USA

[3] CHIRON CORP, EMERYVILLE, CA USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1993年 / 329卷 / 24期

关键词：

D O I：

10.1056/NEJM199312093292405

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acyclovir has been widely used over the past decade as an effective and safe drug for the treatment of infections with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2)1. Resistance to acyclovir was initially noted only in studies of HSV infection in vitro and in animal models,2–4 then it was found in immunocompromised patients, and it has now become a well-documented clinical challenge to the care of patients infected with the human immunodeficiency virus (HIV)4–12. Acyclovir resistance has not been a problem to date in the treatment of immunocompetent people with HSV infection. Although… © 1993, Massachusetts Medical Society. All rights reserved.

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页码：1777 / 1782

页数：6

相关论文

共 44 条

[1] SUCCESSFUL TREATMENT WITH FOSCARNET OF AN ACYCLOVIR-RESISTANT MUCOCUTANEOUS INFECTION WITH HERPES-SIMPLEX VIRUS IN A PATIENT WITH ACQUIRED IMMUNODEFICIENCY SYNDROME [J].

CHATIS, PA ;

MILLER, CH ;

SCHRAGER, LE ;

CRUMPACKER, CS .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (05) :297-300

[2] DIFFERENTIAL ACTIVITY OF POTENTIAL ANTI-VIRAL NUCLEOSIDE ANALOGS ON HERPES-SIMPLEX VIRUS-INDUCED AND HUMAN CELLULAR THYMIDINE KINASES [J].

CHENG, YC ;

DUTSCHMAN, G ;

FOX, JJ ;

WATANABE, KA ;

MACHIDA, H .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1981, 20 (03) :420-423

[3] 2 DISTINCT LOCI CONFER RESISTANCE TO ACYCLOGUANOSINE IN HERPES-SIMPLEX VIRUS TYPE-1 [J].

COEN, DM ;

SCHAFFER, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04) :2265-2269

[4] CHARACTERIZATION OF A DNA-POLYMERASE MUTANT OF HERPES-SIMPLEX VIRUS FROM A SEVERELY IMMUNOCOMPROMISED PATIENT RECEIVING ACYCLOVIR [J].

COLLINS, P ;

LARDER, BA ;

OLIVER, NM ;

KEMP, S ;

SMITH, IW ;

DARBY, G .

JOURNAL OF GENERAL VIROLOGY, 1989, 70 :375-382

[5] EVIDENCE THAT THE ACTIVE-CENTER OF THE HERPES-SIMPLEX VIRUS THYMIDINE KINASE INVOLVES AN INTERACTION BETWEEN 3 DISTINCT REGIONS OF THE POLYPEPTIDE [J].

DARBY, G ;

LARDER, BA ;

INGLIS, MM .

JOURNAL OF GENERAL VIROLOGY, 1986, 67 :753-758

[6] ALTERED SUBSTRATE-SPECIFICITY OF HERPES-SIMPLEX VIRUS THYMIDINE KINASE CONFERS ACYCLOVIR-RESISTANCE [J].

DARBY, G ;

FIELD, HJ ;

SALISBURY, SA .

NATURE, 1981, 289 (5793) :81-83

[7] THE COMPLETE DNA-SEQUENCE OF VARICELLA-ZOSTER VIRUS [J].

DAVISON, AJ ;

SCOTT, JE .

JOURNAL OF GENERAL VIROLOGY, 1986, 67 :1759-1816

[8] VIRUS-RESISTANCE IN CLINICAL-PRACTICE [J].

DEKKER, C ;

ELLIS, MN ;

MCLAREN, C ;

HUNTER, G ;

ROGERS, J ;

BARRY, DW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1983, 12 :137-152

[9] A DOUBLE-BLIND-STUDY OF ORAL ACYCLOVIR FOR SUPPRESSION OF RECURRENCES OF GENITAL HERPES-SIMPLEX VIRUS-INFECTION [J].

DOUGLAS, JM ;

CRITCHLOW, C ;

BENEDETTI, J ;

MERTZ, GJ ;

CONNOR, JD ;

HINTZ, MA ;

FAHNLANDER, A ;

REMINGTON, M ;

WINTER, C ;

COREY, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (24) :1551-1556

[10] CLINICAL ISOLATE OF HERPES-SIMPLEX VIRUS TYPE-2 THAT INDUCES A THYMIDINE KINASE WITH ALTERED SUBSTRATE-SPECIFICITY [J].

ELLIS, MN ;

KELLER, PM ;

FYFE, JA ;

MARTIN, JL ;

ROONEY, JF ;

STRAUS, SE ;

LEHRMAN, SN ;

BARRY, DW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (07) :1117-1125

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