HINDLIMB PROTEIN-METABOLISM IN GROWING SHEEP - EFFECTS OF ACUTE AND CHRONIC INFUSION OF CLENBUTEROL BY CLOSE ARTERIAL AND SYSTEMIC ROUTES

被引：1

作者：

AUROUSSEAU, B ^{[1
]}

CONNELL, A ^{[1
]}

REVELL, DK ^{[1
]}

ROCHA, HJG ^{[1
]}

LOBLEY, GE ^{[1
]}

机构：

[1] ROWETT RES INST,BUCKSBURN AB2 9SB,ABERDEEN,SCOTLAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1993年 / 106卷 / 02期

关键词：

D O I：

10.1016/0742-8413(93)90174-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Close arterial infusion of clenbuterol (0.7 mug/hr) for a 3 hr period led to decreased protein synthesis and degradation (both P < 0.05) across the hind-limb of sheep. 2. Systemic infusion of the drug (14 mug/hr) for a similar period increased blood flow (P < 0.001) through the hind-limb and decreased protein degradation (P < 0.05). 3. Following chronic (7 day) close-arterial infusion of clenbuterol (1.9 mug/hr) hind-limb protein synthesis and degradation again declined (P < 0.05) but this was apparently not recovered during 7 days of drug withdrawal. 4. In consequence, during subsequent systemic infusion of the drug (62 mug/hr) the lower rates of protein metabolism were not altered significantly, despite improved whole nitrogen retention (+30%, P < 0.01). 5. The results are discussed with reference to the differential actions of beta-agonists on the various tissues of the hind-limb.

引用

页码：529 / 535

页数：7

共 37 条

[1] PORCINE SKELETAL-MUSCLE MYOFIBRILLAR PROTEIN-SYNTHESIS IS STIMULATED BY RACTOPAMINE [J].