REGULATION OF THE BETA-GLOBIN LOCUS

被引：87

作者：

CROSSLEY, M

ORKIN, SH

机构：

[1] HOWARD HUGHES MED INST, BOSTON, MA USA

[2] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0959-437X(93)90028-N

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transcription of the human beta-globin gene cluster depends upon upstream regulatory sequences, which are collectively termed the locus control region. Recent studies have provided new insights into how the individual genes of the cluster are regulated through development. The crux of transcriptional activation is how the locus control region communicates with the gene-proximal regulatory elements.

引用

页码：232 / 237

页数：6

共 40 条

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