REQUIREMENT FOR LIM1 IN HEAD-ORGANIZER FUNCTION

被引：649

作者：

SHAWLOT, W ^{[1
]}

BEHRINGER, RR ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT MOLEC GENET,HOUSTON,TX 77030

来源：

NATURE | 1995年 / 374卷 / 6521期

关键词：

D O I：

10.1038/374425a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer.

引用

页码：425 / 430

页数：6

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