CARBON MONOXIDE-INDUCED ARTERIAL HYPOXEMIA

被引：56

作者：

BRODY, JS

COBURN, RF

机构：

[1] Department of Physiology (Graduate Division) and Pulmonary Disease Section, University of Pennsylvania, Veterans Administration Hospital, Philadelphia

来源：

SCIENCE | 1969年 / 164卷 / 3885期

关键词：

D O I：

10.1126/science.164.3885.1297

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inhalation of carbon monoxide produces an increase in the alveolar to arterial oxygen gradient in the presence of veno-arterial shunts or ventilation-perfusion imbalance but has no such effect in normal subjects. The increase in the alveolar to arterial oxygen gradient with rising concentrations of carboxyhemoglobin results from changes induced by carbon monoxide in the shape of the oxyhemoglobin dissociation curve.

引用

页码：1297 / &

共 10 条

[1] CARBOXYHEMOGLOBIN - HEMODYNAMIC AND RESPIRATORY RESPONSES TO SMALL CONCENTRATIONS [J].

AYRES, SM ;

GIANNELL.S ;

ARMSTRON.RG .

SCIENCE, 1965, 149 (3680) :193-&

[2]

AYRES SM, 1966, J CLIN INVEST, V45, P983

[3]

COMROE JH, 1962, LUNG

[4]

Douglas CG, 1912, J PHYSIOL-LONDON, V44, P275

[5] IMPROVED OXYGEN RELEASE - AN ADAPTATION OF MATURE RED CELLS TO HYPOXIA [J].

EDWARDS, MJ ;

NOVY, MJ ;

WALTERS, CL ;

METCALFE, J .

JOURNAL OF CLINICAL INVESTIGATION, 1968, 47 (08) :1851-&

[6]

OSKI FA, UNPUBLISHED

[7] ANALYSIS OF FACTORS AFFECTING PARTIAL PRESSURES OF OXYGEN AND CARBON DIOXIDE IN GAS AND BLOOD OF LUNGS - THEORY [J].

RILEY, RL ;

COURNAND, A .

JOURNAL OF APPLIED PHYSIOLOGY, 1951, 4 (02) :77-101

[8]

ROOT WALTER S., 1965, HANDBOOK PHYSIOL, V2, P1087

[9] The effect of carbon monoxide on the oxyhemoglobin dissociation curve [J].

Roughton, FJW ;

Darling, RC .

AMERICAN JOURNAL OF PHYSIOLOGY, 1944, 141 (01) :0017-0031

[10]

Strieder D J, 1967, Ann Thorac Surg, V4, P523

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