MOLECULAR-WEIGHT-DEPENDENCE OF THE ANTI-COAGULANT ACTIVITY OF HEPARIN

被引：66

作者：

THUNBERG, L

LINDAHL, U

TENGBLAD, A

LAURENT, TC

JACKSON, CM

机构：

[1] UNIV UPPSALA,CTR BIOMED,DEPT MED & PHYSIOL CHEM,S-75123 UPPSALA,SWEDEN

[2] WASHINGTON UNIV,SCH MED,DEPT BIOL CHEM,ST LOUIS,MO 63110

来源：

BIOCHEMICAL JOURNAL | 1979年 / 181卷 / 01期

关键词：

D O I：

10.1042/bj1810241

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inactivation of thrombin and factor X(a) by antithrombin was determined in the presence of heparin fractions of different molecular weights and with high affinity for antithrombin. The ability to potentiate the inactivation of either coagulation factor increased with increasing length of the polysaccharide chain.

引用

页码：241 / 243

页数：3

共 12 条

[1] ANTICOAGULANT PROPERTIES OF HEPARIN FRACTIONATED BY AFFINITY CHROMATOGRAPHY ON MATRIX-BOUND ANTITHROMBIN-3 AND BY GEL-FILTRATION
ANDERSSON, LO
BARROWCLIFFE, TW
HOLMER, E
JOHNSON, EA
SIMS, GEC
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[2] ANDERSSON LO, THROMB RES
[3] STUDIES ON THE MECHANISM OF THE RATE-ENHANCING EFFECT OF HEPARIN ON THE THROMBIN-ANTITHROMBIN-III REACTION
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ANDERSSON, LO
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1979, 93 (01): : 1 - 5
[4] ANTICOAGULANT ACTIVITY OF HEPARIN - SEPARATION OF HIGH-ACTIVITY AND LOW-ACTIVITY HEPARIN SPECIES BY AFFINITY CHROMATOGRAPHY ON IMMOBILIZED ANTITHROMBIN
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[J]. FEBS LETTERS, 1976, 66 (01) : 90 - 93
[5] ANTICOAGULANT ACTIVITY OF HEPARIN - ISOLATION OF ANTITHROMBIN-BINDING SITES
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[J]. FEBS LETTERS, 1976, 69 (01) : 51 - 54
[6] STUDIES ON BOVINE FACTOR X .2. CHARACTERIZATION OF PURIFIED FACTOR X . OBSERVATIONS ON SOME ALTERATIONS IN ZONE ELECTROPHORETIC AND CHROMATOGRAPHIC BEHAVIOR OCCURRING DURING PURIFICATION
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[J]. BIOCHEMISTRY, 1968, 7 (12) : 4506 - &
[7] SEPARATION OF ACTIVE AND INACTIVE FORMS OF HEPARIN
LAM, LH
SILBERT, JE
ROSENBERG, RD
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 69 (02) : 570 - 577
[8] INTERACTION BETWEEN POLYSACCHARIDES AND OTHER MACROMOLECULES .27. MOLECULAR-WEIGHT-DEPENDENCE OF ANTI-COAGULANT ACTIVITY OF HEPARIN
LAURENT, TC
TENGBLAD, A
THUNBERG, L
HOOK, M
LINDAHL, U
[J]. BIOCHEMICAL JOURNAL, 1978, 175 (02) : 691 - 701
[9] LINDAHL U, P NATL ACAD SCI US
[10] CATALYTIC ROLE FOR HEPARIN - EVIDENCE FOR A TERNARY COMPLEX OF HEPARIN COFACTOR THROMBIN AND HEPARIN
POMERANTZ, MW
OWEN, WG
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 535 (01) : 66 - 77

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