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CHANGING SENSITIVITY OF PUBERTAL GONADAL HYPOTHALAMIC FEEDBACK MECHANISM IN MAN

被引：139
作者：
KULIN, HE
GRUMBACH, MM
KAPLAN, SL
机构：
[1] Department of Pediatrics, University of California, San Francisco Medical Center, San Francisco
来源：
SCIENCE | 1969年 / 166卷 / 3908期
关键词：
D O I：
10.1126/science.166.3908.1012
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Clomiphene citrate in doses which stimulate gonadotropin production in the adult suppresses urinary follicle stimulating hormone (FSH) excretion and plasma testosterone concentration in prepubertal children. Such results indicate that feedback between gonad and hypothalamus is operative and highly sensitive in prepubertal humans. Puberty in man, as in the rat, is accompanied by a decrease in the sensitivity of the feedback mechanism.
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页码：1012 / +
页数：1
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