FRAGMENTATION DURING THE FORMIC-ACID FORMALDEHYDE (ESCHWEILER-CLARKE) METHYLATION OF POLYAMINES

被引：12

作者：

ALDER, RW

COLCLOUGH, D

MOWLAM, RW

机构：

[1] School of Chemistry, University of Bristol, Bristol

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 52期

关键词：

D O I：

10.1016/0040-4039(91)80583-R

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Eschweiler-Clarke methylations of both acyclic and cyclic polyamines can lead to methylation products of fragments of the original polyamine; thus 1,5,9,13-tetra-azatridecane yields 1,1,3,3-tetramethylpropanediamine exclusively and 1,5,9-triazacyclododecane gives 45% 1,5,9-trimethyl-1,5,9-triazacyclodecane and 45% 2,6,10-trimethyl-2,6,10-triazaundecane.

引用

页码：7755 / 7758

页数：4

共 32 条

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