FOWLPOX VIRUS RECOMBINANT ENCODING THE MEASLES-VIRUS FUSION PROTEIN - PROTECTION OF MICE AGAINST FATAL MEASLES ENCEPHALITIS

被引：27

作者：

WILD, F

GIRAUDON, P

SPEHNER, D

DRILLIEN, R

LECOCQ, JP

机构：

[1] TRANSGENE SA,11 RUE MOLSHEIM,F-67000 STRASBOURG,FRANCE

[2] UNIV CLAUDE BERNARD LYON 1,CNRS,F-69372 LYONS 08,FRANCE

[3] UNIV STRASBOURG 1,VIROL LAB,INSERM,U74,F-67070 STRASBOURG,FRANCE

来源：

VACCINE | 1990年 / 8卷 / 05期

关键词：

ELISA; Fowlpox virus; measles virus; mice;

D O I：

10.1016/0264-410X(90)90243-F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A recombinant Fowlpox virus engineered to encode the measles virus fusion protein was shown to protect mice against a challenge measles infection. A vaccine dose of about 106 p.f.u. was needed to protect nearly 100% of the animals. Mice failed to develop a significant level of antibodies directed against measles virus suggesting that other components of the immune system may be involved. © 1990.

引用

页码：441 / 442

页数：2

共 6 条

[1] CONSTRUCTION OF RECOMBINANT FOWLPOX VIRUSES AS VECTORS FOR POULTRY VACCINES
BOYLE, DB
COUPAR, BEH
[J]. VIRUS RESEARCH, 1988, 10 (04) : 343 - 356
[2] PROTECTION OF MICE FROM FATAL MEASLES ENCEPHALITIS BY VACCINATION WITH VACCINIA VIRUS RECOMBINANTS ENCODING EITHER THE HEMAGGLUTININ OR THE FUSION PROTEIN
DRILLIEN, R
SPEHNER, D
KIRN, A
GIRAUDON, P
BUCKLAND, R
WILD, F
LECOCQ, JP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (04) : 1252 - 1256
[3] CONSTRUCTION OF FOWLPOX VIRUS VECTORS WITH INTERGENIC INSERTIONS - EXPRESSION OF THE BETA-GALACTOSIDASE GENE AND THE MEASLES-VIRUS FUSION GENE
SPEHNER, D
DRILLIEN, R
LECOCQ, JP
[J]. JOURNAL OF VIROLOGY, 1990, 64 (02) : 527 - 533
[4] RECOMBINANT FOWLPOX VIRUS INDUCING PROTECTIVE IMMUNITY IN NON-AVIAN SPECIES
TAYLOR, J
WEINBERG, R
LANGUET, B
DESMETTRE, P
PAOLETTI, E
[J]. VACCINE, 1988, 6 (06) : 497 - 503
[5] PROTECTIVE IMMUNITY AGAINST AVIAN INFLUENZA INDUCED BY A FOWLPOX VIRUS RECOMBINANT
TAYLOR, J
WEINBERG, R
KAWAOKA, Y
WEBSTER, RG
PAOLETTI, E
[J]. VACCINE, 1988, 6 (06) : 504 - 508
[6] ISOLATION AND CHARACTERIZATION OF A DEFECTIVE MEASLES-VIRUS FROM A SUB-ACUTE SCLEROSING PANENCEPHALITIS PATIENT
WILD, TF
GIRAUDON, P
BERNARD, A
HUPPERT, J
[J]. JOURNAL OF MEDICAL VIROLOGY, 1979, 4 (02) : 103 - 114

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