SYNTHESIS OF 1'-DEOXYPSICOFURANOSYL-DEOXYNUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS

被引：9

作者：

FAIVREBUET, V ^{[1
]}

GROUILLER, A ^{[1
]}

DESCOTES, G ^{[1
]}

机构：

[1] UNIV LYON 1,CHIM ORGAN LAB 2,CNRS,URA 463,43 BLVD 11 NOVEMBRE 1918,F-69622 VILLEURBANNE,FRANCE

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 07期

关键词：

D O I：

10.1080/07328319208021183

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Various routes to the targets 1, 2, 3, 1-deoxy-psicofuranosyl nucleoside analogues related to anti-HIV agents, are reported. Two routes afforded their 6'-benzylated derivatives 9, 10 and 15. Only the epoxide 12 and deoxynucleosides 19 and 22 were able to be deprotected leading in the first case to 16 and its ring opening derivative 17 and in the second case to 20 and to the target 3.

引用

页码：1411 / 1424

页数：14

共 12 条

[1] NEW METHOD FOR DEOXYGENATION OF SECONDARY ALCOHOLS
BARTON, DHR
MCCOMBIE, SW
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1975, (16): : 1574 - 1585
[2] BIEG T, 1985, SYNTHESIS-STUTTGART, P76
[3] GENERAL SYNTHESES OF 2',3'-DIDEOXYNUCLEOSIDES AND 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES
CHU, CK
BHADTI, VS
DOBOSZEWSKI, B
GU, ZP
KOSUGI, Y
PULLAIAH, KC
VANROEY, P
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (09) : 2217 - 2225
[4] FAIVREBUET V, UNPUB
[5] FAIVREBUET V, 1991, THESIS U C BERNARD L
[6] GROUILLER A, 1987, SYNTHESIS-STUTTGART, P1121
[7] NUCLEIC-ACID RELATED-COMPOUNDS .43. A CONVENIENT PROCEDURE FOR THE SYNTHESIS OF 2' AND 3'-KETONUCLEOSIDES
HANSSKE, F
ROBINS, MJ
[J]. TETRAHEDRON LETTERS, 1983, 24 (15) : 1589 - 1592
[8] PREPARATION OF 1-(2,3-DIDEOXY-BETA-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE (D4T)1 AND 2',3'-DIDEOXYADENOSINE (DDA) - GENERAL-METHODS FOR THE SYNTHESIS OF 2',3'-OLEFINIC AND 2',3'-DIDEOXY NUCLEOSIDE ANALOGS ACTIVE AGAINST HIV
MANSURI, MM
STARRETT, JE
WOS, JA
TORTOLANI, DR
BRODFUEHRER, PR
HOWELL, HG
MARTIN, JC
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (20) : 4780 - 4785
[9] NICHOL CA, 1975, HDB EXP PHARM 2, V38, P434
[10] POTENTIAL ANTICANCER AGENTS .73. SYNTHESIS OF DERIVATIVES OF 1-DEOXYPSICOSE
REIST, EJ
HART, PA
GOODMAN, L
BAKER, BR
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (05) : 1722 - &

← 1 2 →