SYNTHESIS OF 1'-DEOXYPSICOFURANOSYL-DEOXYNUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS

被引:9
作者
FAIVREBUET, V [1 ]
GROUILLER, A [1 ]
DESCOTES, G [1 ]
机构
[1] UNIV LYON 1,CHIM ORGAN LAB 2,CNRS,URA 463,43 BLVD 11 NOVEMBRE 1918,F-69622 VILLEURBANNE,FRANCE
来源
NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 07期
关键词
D O I
10.1080/07328319208021183
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Various routes to the targets 1, 2, 3, 1-deoxy-psicofuranosyl nucleoside analogues related to anti-HIV agents, are reported. Two routes afforded their 6'-benzylated derivatives 9, 10 and 15. Only the epoxide 12 and deoxynucleosides 19 and 22 were able to be deprotected leading in the first case to 16 and its ring opening derivative 17 and in the second case to 20 and to the target 3.
引用
收藏
页码:1411 / 1424
页数:14
相关论文
共 12 条