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THE HUMAN-COMPLEMENT C4B STEROID 21-HYDROXYLASE (CYP21) AND COMPLEMENT C4A/21-HYDROXYLASE PSEUDOGENE (CYP21P) INTERGENIC SEQUENCES - COMPARISON AND IDENTIFICATION OF POSSIBLE REGULATORY ELEMENTS

被引：8
作者：
DONOHOUE, PA
COLLINS, MM
机构：
[1] The University of Iowa, Department of Pediatrics Division of Endocrinology
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 01期
关键词：
D O I：
10.1016/S0006-291X(05)80801-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We determined the 1.8 kb intergenic sequences between the human complement C4B gene and the active steroid 21 hydroxylase gene in two subjects, and between the C4A gene and the steroid 21-hydroxylase pseudogene in one subject. Comparison of these sequences with each other and with published homologues revealed no differences which were unique to either intergenic region. Sequence analysis revealed two copies of an AGGTCA motif in all sequences. This motif is common to steroidogenic enzyme gene promoters and to the response elements for nuclear hormone receptors. Similarities with human enhancers were also found. © 1992 Academic Press, Inc.
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页码：256 / 262
页数：7
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