CADAVERIC RENAL-TRANSPLANTATION IN CHILDREN UNDER 5 YEARS OF AGE

被引：28

作者：

FITZPATRICK, MM

DUFFY, PG

FERNANDO, ON

BARRATT, TM

DILLON, MJ

TROMPETER, RS

机构：

[1] Department of Paediatric Nephrology, Institute of Child Health, London, WC1N 1EH

来源：

PEDIATRIC NEPHROLOGY | 1992年 / 6卷 / 02期

关键词：

CADAVERIC RENAL TRANSPLANTATION; CHILDREN UNDER 5 YEARS; RENAL VENOUS THROMBOSIS;

D O I：

10.1007/BF00866302

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

From March 1987 to August 1990 23 cadaveric renal transplants were performed in 19 children under the age of 5 years at the time of transplantation. The mean age of the recipients was 3.3 years (range 1.3-4.7) and the mean weight 13.0 kg (range 9.3 - 19.2). The mean donor age was 7.8 years (range 1.5-.5). All children received triple immunosuppression with prednisolone, cyclosporin A and azathioprine, and 4 who had 2 grafts during this period also received antithymocyte globulin at the time of the second transplant. Patient survival is 100%. Actuarial first cadaveric graft survival was 57% at 1 year and remains unchanged at 3 years. There were 10 graft losses, 4 were associated with renal venous thrombosis without apparent rejection. Two were lost due to acute vascular rejection with associated renal venous thrombosis, and the remaining 4 losses followed cellular or chronic vascular rejection. The mean glomerular filtration rate +/- SD was 51.4 +/- 23.6 ml/min per 1.73 m2 (n = 11) at 1 year and 43.5 +/- 25.3 at 2 years (n = 6). The mean height standard deviation score improved from -2.2 +/- 1.1 at the time of transplantation to -1.3 +/- 1.0 1 year post transplant (n = 11). The immunosuppression was well tolerated with a low incidence of side effects. Cadaveric renal transplantation remains a difficult but rewarding undertaking in children under 5 years of age.

引用

页码：166 / 171

页数：6

共 28 条

[1] Arbus G.S., Geary D.F., McLorie G.A., Major M.L., Berdock S.E., Freedman L., Baumal R., Pediatric renal transplants: a Canadian perspective, Kidney Int, 30, pp. S31-S34, (1986)
[2] Ettenger R.B., Rosenthal J.T., Marik J., Salusky I.B., Kamil E., Malekzadeh M.H., Fine R.N., Successful cadaveric renal transplantation in infants and young children, Transplant Proc, 21, pp. 1707-1708, (1989)
[3] Najarian J.S., Frey M.D., Matas A.J., Gillingham K.J., So S.K.S., Cook M., Chavers B., Mauer S.M., Nevins T.E., Renal transplantation in infants, Ann Surg, 212, pp. 353-365, (1990)
[4] So S.K.S., Mauer S.M., Nevins T.E., Fryd D.S., Sutherland D.E.R., Ascher N.L., Simmons R.L., Najarian J.S., Current results in pediatric renal transplantation at the University of Minnesota, Kidney Int, 30, pp. S25-S30, (1986)
[5] Rizzoni G., Malekzadeh M.H., Pennisi A.J., Ettenger R.B., Uittenbogaart C.H., Fine R.N., Renal transplantation in children less than 5 years of age, Arch Dis Child, 55, pp. 532-536, (1980)
[6] Koffmann C.G., Rigden S.P.A., Bewick M., Chantler C., Haycock G.B., Renal transplantation in children less than five years of age, Transplant Proc, 21, pp. 2001-2002, (1989)
[7] Alexander S.R., Arbus G.S., Butt K.M.H., Conley S., Fine R.N., Greifer I., Gruskin A.B., Harmon W.E., McEnery P.T., Nevins T.E., Nogueira N., Salvatierra O., Tejani A., The 1989 report of the North American Pediatric Renal Transplant Cooperative Study, Pediatr Nephrol, 4, pp. 542-553, (1990)
[8] Groenewoud A.F., Persijn G.G., D'Amaro J., de Lange P., Cohen B., Influence of immunosuppressive therapy, HLA matching and donor age on long term cadaveric pediatric renal allograft survival, Transplant Proc, 21, pp. 1683-1684, (1989)
[9] Sawchuk R.J., Cartier L.L., Liquid chromatographic determination of cyclosporin A in blood and plasma, Clin Chem, 27, pp. 1368-1371, (1981)
[10] Chantler C., Barratt T.M., The estimation of glomerular filtration rate in children from the plasma clearance of 51-chromium edetic acid, Arch Dis Child, 47, pp. 613-617, (1972)

← 1 2 3 →