PH-POSITIVE LEUKEMIA - A TRANSGENIC MOUSE MODEL

被引：8

作者：

GROFFEN, J

VONCKEN, JW

KAARTINEN, V

MORRIS, C

HEISTERKAMP, N

机构：

[1] Section of Molecular Diagnosis, Department of Pathology, Children's Hospital of Los Angeles, Los Angeles

[2] Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, Christchurch

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 11卷

关键词：

LEUKEMIA; BCR/ABL; MOUSE MODEL; TRANSGENIC;

D O I：

10.3109/10428199309047857

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The presence of the BCR/ABL chimeric gene is the hallmark of defined types of human leukemia. To increase our knowledge of the oncogenic processes and to develop a model for this type of leukemia we generated a BCR/ABL (P190) transgenic mouse line. Over 95% of mice of this line die of leukemia or leukemia/lymphoma within 35-200 days of age. Karyotypically visible genetic alterations were absent from the early stages of BCR/ABL generated leukemia. A high frequency of aneuploidy was found in advanced leukemia indicating a primary and pivotal role for BCR/ABL in leukemogenesis. Moreover, the data suggest that BCR/ABL has a destabilizing effect on the regulation of the cell cycle. BCR/ABL expression was also found in tissues other than hematopoietic cells. However, this did not result in the development of solid tumors, strongly suggesting that the oncogenicity of BCR/ABL is limited to the hematopoietic lineage.

引用

页码：19 / 24

页数：6

共 23 条

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