UPTAKE OF 14C GLYCINE BY SPINAL CORD

THERE is much evidence that glycine may be an inhibitory transmitter in the mammalian spinal cord. The distribution of this amino-acid in the cat spinal cord has been related to the presence of inhibitory interneurones1. Glycine hyperpolarizes spinal motoneurones2, and the changes in membrane permeability which it produces seem to be similar to those produced by a spinal inhibitory synaptic transmitter3. Strychnine, which reduces spinal post-synaptic inhibition, blocks the effects of glycine on spinal motoneurones4. © 1969 Nature Publishing Group.