SELECTIVE 17-ALPHA-ALKYLATION OF CORTIENIC ACID-DERIVATIVES IN A SOLID-LIQUID BIPHASIC SYSTEM

被引：5

作者：

DRUZGALA, P ^{[1
]}

BODOR, N ^{[1
]}

机构：

[1] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,CTR DRUG DESIGN & DELIVERY,BOX J-497,GAINESVILLE,FL 32610

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 08期

关键词：

D O I：

10.1080/00397919008052820

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1 lβ,17α-Dihydroxy-3-oxoandrost-4-ene 17β-carboxylic acid (cortienic acid), or its methyl ester, are efficiently and selectively alkylated at the 17a-position using methyl iodide in a solid-liquid biphasic system consisting of potassium hydroxide and dimethyl sulfoxide. When a higher alkyl halide homolog is used, it is necessary to protect the α-enone function. Copyright © 1990 by Taylor & Francis Group. All rights reserved.

引用

页码：1133 / 1141

页数：9

共 7 条

[1] [Anonymous], ADV DRUG RES
[2] BODOR N, 1988, TOPICAL CORTICOSTERO, pP13
[3] DOUBLE-BOND MIGRATION OVER SOLID KOH SUSPENDED IN APROTIC-SOLVENTS
DINCAN, E
VIOUT, P
[J]. TETRAHEDRON, 1984, 40 (18) : 3421 - 3424
[4] RAPID, SIMPLE, AND MILD PROCEDURE FOR ALKYLATION OF PHENOLS, ALCOHOLS, AMIDES AND ACIDS
JOHNSTONE, RAW
ROSE, ME
[J]. TETRAHEDRON, 1979, 35 (18) : 2169 - 2173
[5] KEMP AD, 1954, J BIOL CHEM, V210, P123
[6] On the components of adrenocortico and related matter (26 Announcement) Evidence for the affinity of substance S to the 17(beta)-sequence
Reichstein, T
Meystre, C
von Euw, J
[J]. HELVETICA CHIMICA ACTA, 1939, 22 : 1107 - 1113
[7] VONEUW J, HELV CHIM ACTA, V30, P205

← 1 →