EFFECT OF 8-HYDROXY-2-(DI-NORMAL-PROPYLAMINO)-TETRALIN ON THE TRYPTOPHAN-INDUCED INCREASE IN 5-HYDROXYTRYPTOPHAN ACCUMULATION IN RAT-BRAIN

被引：27

作者：

FERNSTROM, MH

MASSOUDI, MS

FERNSTROM, JD

机构：

[1] Department of Psychiatry University, Pittsburgh School of Medicine Pittsburgh

来源：

LIFE SCIENCES | 1990年 / 47卷 / 04期

关键词：

D O I：

10.1016/0024-3205(90)90585-F

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The injection of 8-hydroxy-2-(di-n-propylamino)-tetralin [8-OH-DPAT] reduced 5-hydroxytryptophan accumulation in vivo in rat cerebral cortex, hypothalamus and brainstem. Brain trytophan levels were unaffected. Dose-related increases in 5-hydroxytryptophan accumulation produced by single injections of L-tryptophan (0, 25, 75 mg/kg ip) were substantially diminished by pretreatment with 8-OH-DPAT. The drug did not affect the tryptophan-induced increments in brain tryptophan level. Since 8-OH-DPAT is known to reduce the activity of serotonin neurons in vivo, these results suggest that when serotonin neutrons are relatively inactive, the ability of an injection of tryptophan to stimulate serotonin synthesis is greatly attenuated. © 1990.

引用

页码：283 / 289

页数：7

共 38 条

[1]

ASHCROFT GW, 1965, J NEUROCHEM, V12, P483, DOI 10.1111/j.1471-4159.1965.tb06775.x

[2]

BANNON MJ, 1983, PHARMACOL REV, V35, P53

[3] ELECTROPHYSIOLOGICAL ASSESSMENT OF PUTATIVE ANTAGONISTS OF 5-HYDROXYTRYPTAMINE RECEPTORS - A SINGLE-CELL STUDY IN THE RAT DORSAL RAPHE NUCLEUS [J].