RISK-FACTORS FOR CARDIOVASCULAR MALFORMATIONS IN FINLAND

被引：43

作者：

TIKKANEN, J

HEINONEN, OP

机构：

[1] National Public Health Institute, Helsinki, SF-00140

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1990年 / 6卷 / 04期

关键词：

CARDIOVASCULAR MALFORMATIONS; RISK FACTORS; EXPOSURES DURING PREGNANCY;

D O I：

10.1007/BF00151707

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The possible effects of genetic and environmental risk factors during pregnancy on the occurrence of cardiovascular malformations in the offspring was studied in 408 cases and 756 controls. The cases represented all registered cardiovascular malformations reported in Finland during 1982-1983. The controls were randomly selected from all babies born during the same period. Both the case and control mothers were interviewed by midwives approximately three months after delivery using a structured questionnaire. The parents of cases had more cardiovascular malformations than parents of the controls. Maternal alcohol consumption seemed to double the risk of atrial septal defect (OR = 1.9, CI95 1.0-3.4). Maternal exposure to dyes, lacquers or paints was a significant risk factor for conal septal defects (OR = 2.9, CI95 = 1.2-7.5). Maternal upper respiratory infection was twice as common among the hypoplastic left ventricle group as among the controls. Maternal smoking, coffee, tea and cola consumption and intake of acetylsalicylic acid were equally prevalent in both groups. Maternal exposure to anesthetic gases, wood preservatives or pesticides was not associated with the risk of cardiovascular malformations. The study confirms that very little is known of the etiology of congenital heart disease.

引用

页码：348 / 356

页数：9

共 28 条

[1]

Blomqvist O., Ericson A., Kallen B., Westerholm P., Delivery outcome for women working in the pulp and paper industry, Scand J. Work Environ. Health, 7, pp. 114-118, (1981)

[2]

Bound J.P., Logan W.F.W.E., Incidence of congenital heart disease in Blackpool 1957–1971, Br. Heart J., 39, pp. 445-450, (1977)

[3]

Campbell M., Incidence of cardiac malformations at birth and later, and neonatal mortality, Br. Heart J., 35, pp. 189-200, (1973)

[4]

Carlgren L.E., Ericson A., Kallen B., Monitoring of congenital cardiac defects, Pediatr. Cardiol., 8, pp. 247-256, (1987)

[5]

Corone P., Bonaiti C., Feingold J., Fromonts Dominique B.-B., Familiar congenital heart disease: How are the various types related?, Am. J. Cardiol., 36, pp. 793-796, (1983)

[6]

Ferencs C., Rubin J.D., McCarter R.J., Brenner J.I., Neil C.A., Perry L.W., Hepner S.I., Downing J.W., Congenital heart disease: Prevalence at livebirth. The Baltimore-Washington Infant Study, Am. J. Epidemiol., 121, pp. 31-36, (1985)

[7]

Grabitz R.G., Joffres M.R., Collins-Nakai R.L., Congenital heart disease: Incidence in the first year of life. The Alberta Heritage Pediatric Cardiology Program, Am. J. Epidemiol., 128, pp. 381-388, (1988)

[8]

Hansson E., Jansa S., Wande H., Kallen B., Ostlund E., Pregnancy outcome for women working in laboratories in some of the pharmaceutical industries in Sweden, Scand. J. Work Environ. Health, 6, pp. 131-134, (1980)

[9]

Heinonen O.P., Risk factors for congenital heart disease. A prospective study, Birth defects: Risks and consequences, pp. 221-264, (1976)

[10]

Hemminki K., Yineis P., Extrapolation of the evidence on teratogenicity of chemicals between humans and experimental animals. Chemicals other than drugs, Teragenesis Carcinog. Mutagen, 5, pp. 251-318, (1985)

← 1 2 3 →