EFFECTS OF ANTIFLAMMINS ON ENDOTOXIN-INDUCED UVEITIS IN RATS

被引：40

作者：

CHAN, CC

NI, M

MIELE, L

CORDELLAMIELE, E

FERRICK, M

MUKHERJEE, AB

NUSSENBLATT, RB

机构：

[1] HOWARD HUGHES MED INST,BETHESDA,MD

[2] NICHHD,HUMAN GENET BRANCH,DEV GENET BRANCH,BETHESDA,MD 20892

来源：

ARCHIVES OF OPHTHALMOLOGY | 1991年 / 109卷 / 02期

关键词：

D O I：

10.1001/archopht.1991.01080020124058

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Antiflammins are phospholipase A2-inhibitory, anti-inflammatory, synthetic oligopeptides derived from the region of the highest amino-acid sequence similarity between uteroglobin and lipocortin I. Endotoxin-induced uveitis is a model for anterior uveitis of the eye, which has been suggested to be induced through phospholipase A2 activation. In a preliminary report we demonstrated that topical administration of antiflammins could inhibit endotoxin-induced uveitis in rats. In this study, the anti-inflammatory effects of antiflammins were compared with those of corticosteroids on endotoxin-induced uveitis as measured by phospholipase A2 enzyme activity, inflammatory cell counts in the aqueous humor, and histopathologic features. Antiflammins are as effective as corticosteroids in their ability to suppress endotoxin-induced uveitis.

引用

页码：278 / 281

页数：4

共 19 条

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